Our bodies are governed by hormones. Testosterone in men and estrogen in women are intense. However, these hormones do not occur in a single structure as thought. For example, the estrogen hormone is produced in three different forms, and the most effective one is the Estradiol (E2) form. Estradiol (E2) form is the most concentrated and most effective form of estrogen in women of reproductive age.
Estradiol (E2) and other forms of estrogen are actually produced as cholesterol, and when they enter the bloodstream, they initiate the directing chemical reactions that are their main task. What is Estradiol (E2), a kind of estrogen form that provides many functions in female biology, especially the regulation of the menstrual cycle, how many it should be, what does it indicate low and high, let’s examine it in all details.
Let’s start with the basics, what is Estradiol (E2)?
Estradiol (E2) is one of the most common forms of estrogen in women. Estradiol (E2) form is the most intensely produced and most effective form of estrogen during the period called the reproductive age of women, which lasts from the first to the last menstruation. Other forms of estrogen are called estrone (E1) and estriol (E3).
So what does Estradiol (E2) do?
Estradiol (E2) and other estrogen forms are produced as a kind of cholesterol by the mammary and adrenal glands, especially the ovaries, and are secreted from there and mixed with the blood. These hormones create chemical reactions that control the functions of organs and cells, and as a result of the reaction, an electrical impulse is sent from the brain.
Estradiol (E2) and other forms of estrogen appear at puberty and initiate the body’s process of undergoing changes in line with female biology. These hormones regulate women’s menstrual cycles, control mental health, support bone health, balance cholesterol levels and protect against heart disease. Estradiol (E2) and other forms of estrogen are why women have fewer heart attacks and have a lower risk of heart disease.
What should be the ideal Estradiol (E2) value?
Estradiol (E2), which is a type of estrogen, can be found intensely in women, but it can be very low in men. A special test called Estradiol test is applied to measure the Estradiol (E2) value in the person’s body. The ideal reference range of Estradiol (E2) value, which is evaluated on a picogram measure in one millimeter of blood, was determined as 15 – 350 pg / ml. In women in the menopausal phase, this rate is lower than 10 picograms. In women who are in the menstrual cycle, this value can change frequently.
What should the Estradiol (E2) value be to get pregnant?
Estradiol (E2) value is important for all biological functions of the woman, as well as for the formation of pregnancy. This value is actively followed, especially during the IVF treatment process. Women with an estradiol (E2) value of 80 pg/ml and above are considered to have a low chance of pregnancy. The value considered ideal and with a high chance of pregnancy is below 50 pg/ml. Of course, keep in mind that this rate may vary from person to person.
Why does Estradiol (E2) drop, which is sometimes considered normal?
- menopause period
- A genetic disorder called Turner syndrome, which is thought to be inherited by the X chromosome
- Early menopause, also called ovarian insufficiency, causes the ovaries to become dysfunctional, usually before age 40.
- Disruption of estrogen synthesis due to insufficient fat in the body
- Disorders of the pituitary gland such as hypopitutiarism
- Hypogonadism, in which the production of hormones in the ovaries is not sufficient
Here are some of the conditions, diseases and disorders that cause low estradiol (E2). It is considered normal to have low Estradiol (E2) in people who have not yet entered puberty or who are in the menopause period.
Symptoms of low estradiol (E2):
- Feeling pain during sexual intercourse due to decreased vaginal secretion
- susceptibility to urinary tract infections
- Irregularity in menstruation
- no periods
- feeling of hot flashes
- Emotional swings
- Sensitivity in the breasts
- Shrinking of the breasts
- Headache
- feeling of tiredness
- Distractibility
- Depression
- Weakness of bones and susceptibility to fracture
The symptoms of low estradiol (E2) are generally like this. In fact, not all of these are considered symptoms. Some of them are complaints that are expected to occur in the body as a result of prolonged low Estradiol (E2). In other words, the absence of one of them does not mean that there is no low Estradiol (E2).
It may not always be natural: Why does the Estradiol (E2) value rise?
- entering puberty early
- Tumor formation in the ovaries or testicles
- gynecomastia
- hyperthyroidism
- Cirrhosis
Here are some of the conditions, diseases and disorders that cause high estradiol (E2). In fact, elevation of Estradiol (E2) and other forms of estrogen is generally considered a natural state. However, this height may attract attention from time to time, and one of these reasons may lie behind it.
Symptoms of high estradiol (E2):
- bloated feeling
- Edema in the breast
- breast tenderness
- Lump in breast tissue and risk of breast cancer
- Increase or decrease in sexual desire
- Menstrual irregularity, increase and breakthrough bleeding
- Premenstrual syndrome complaints
- emotional swings
- Headache
- anxiety state
- Panic attack
- Hand and foot chills
- Getting fat
- sleep problems
- hair loss
- Weakness
- memory problems
The symptoms of high estradiol (E2) are generally like this. In fact, not all of these are considered symptoms. Some of them are complaints that are expected to occur in the body as a result of prolonged Estradiol (E2) elevation. In other words, the absence of one of them does not mean that there is no Estradiol (E2) elevation.
When should you go to the doctor?
It is not possible for the person to understand by himself that he is experiencing low or high Estradiol (E2) in general, it is necessary to focus on the symptoms. Of course, the most obvious of these symptoms is the irregularities in the menstrual cycle. It is normal to see such irregularities from time to time, but in cases where they become chronic, they should be examined.
We answered questions such as what is the estrogen form Estradiol (E2), which has important tasks such as regulating the menstrual cycle in women, how much should it be, what does low and high mean. What we describe is for informational purposes only. As with all health issues, remember that you should get the most accurate and specific information about Estradiol (E2) and other estrogen forms from a specialist physician.
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