A new study in UC San Francisco (UCSF) lensed the effects of normal vitamin B12 levels on cognitive health. The results of the research have shown that vitamin B12 levels, which are accepted as ‘normal’ today, may adversely affect brain functions, especially in elderly individuals.

Normal B12 levels may not be enough for brain health

Vitamin B12 plays a role in many vital functions from DNA synthesis to the formation of red blood cells in our body, from nervous system health to energy production. These vitamins, mostly from animal foods, can be obtained by means of enriched foods for vegans and vegetarians. However, UCSF researchers emphasize how it is used by the body beyond the blood levels in vitamin.

Within the scope of the research, the B12 vitamin levels of 231 healthy participants who are aged 71 were examined. In the study, especially on the active form (Holo-TC) and inactive form (HOLO-HC) stored in the liver, which can be used directly by cells with two forms of vitamin, were focused on. The results showed that low active B12 levels slowed the cognitive process rate and this effect became more pronounced with age.

Researchers have detected more ‘White Cevher Hyperintensitis’ (WMH) for participants with low active B12 levels with magnetic resonance imaging (MRI) scans. These findings point to small damage areas in the brain tissue and are associated with aging, weak circulation or neurological diseases. Surprisingly, the high levels of the inactive B12 form were found to be linked to an increase in protein levels associated with Alzheimer’s disease.

This study, which has significant consequences for current clinical applications, shows that the reference intervals for vitamin B12 should be updated. Normal values ​​that are considered to be 148-748 PMol/L in the United States, 135-650 pmol/L in Australia and 115-740 pmol/l in the United Kingdom may not be sufficient to maintain cognitive health, especially in elderly individuals.