The aging of every living thing over time eventually causes the living thing to die due to natural causes resulting from aging. But science has been trying to find a way to prevent aging for a very long time. Scientists from the Salk Institute in the USA broke new ground in history with their newly published work.
Scientists were able to modify the cells of mice using the genes OCT4, SOX2, KLF4 and MYC, known as “Yamanaka factors”. Thanks to this change, the cells of the mice became younger than they were. In other words, the cells became younger as if they had traveled in time.
The scientific world succeeded in slowing down aging
As part of the study, scientists tested variations of the cellular rejuvenation approach on healthy mice as they age. Mice aged 15 months to 22 months, or 50 to 70 years old when converted to human age, were given regular doses of Yamanaka factors. Mice 12 – 22 months old (35 – 70 human years old) were then given the same treatment for only one month in a group of 25 months old (80+) mice.
As a result of testing, the scientists found that the treated animals began to resemble young mouse individuals in tissues such as kidneys and skin patterns. However, test subjects’ cells regenerated faster when injured. Their body’s metabolic molecules also showed no age-related changes.
But tests also showed something else. This treatment, which appears to inhibit aging, only worked in mice that were regularly injected with Yamanaka factors over long periods of time. No similar effect was seen in mice treated for one month, such as mice older than 25 months of age. The scientists will therefore now analyze prospectively how long-term treatment plans change certain molecules.
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