Scientists have announced that a mouse with two male parents managed to survive for the first time. This development represents a great breakthrough in the field and has the potential to influence many fields of science from regenerative medicine to protection. In addition, the mammal reproductive understanding of our understanding of the change.

Researchers had previously worked on mice with two mothers. However, attempts to do the same thing for mice with two fathers by deriving an egg cell from the male pluripotent stem cells and fertilizing it with a sperm taken from another man did not succeed. After the embryos developed to a point, they stopped growth by preventing a process known as genomic suppression.

This occurs when certain material or patternal genes are closed during development and are considered as a fundamental obstacle to mammals. The team used a CRISPR/CAS9 -based gene editing technology to target 20 gene responsible for suppression to overcome these restrictions.

Zhi-Kun Li of the Chinese Academy of Sciences, said in a statement, “These genes exhibit different expressions of expressions depending on the parental genome and are considered a great potential obstacle to uniform reproduction. Our method has allowed us to change these genes by overcoming difficulties that prevent the creation of mice that can survive before. ”

“Two Fathers” Mouse

Thanks to this process, the team managed to produce two fatherly mice that could live up to adulthood for the first time in the world. In addition, Li said that this success was not achieved by changing the deadly stamped areas that caused the death of the embryo. Instead, genes, most of them concerning excessive growth characteristics, have been gradually arranged and thus adults that could live.

In addition, the researchers found that the embryonic stem cells showed developed developmental efficiency compared to controls and had advanced cloning efficiency compared to the natural similar of two paternity mice. This finding suggests that the new method can be used in different applications. New techniques developed to regulate suppressed genes may have significant consequences in regenerative medicine and cloning research, including stem cell therapies.

The findings offer strong evidence that the primary obstacle to uniform reproduction in mammals has strong evidence of repression. However, as always in such groundbreaking breakthroughs, this study has some limitations.

“Unlimited success” has not yet been achieved

Although the research allowed mice to reach adulthood for the first time, more than half could not reach adulthood, and the survival rates of the reaching were relatively low. Most of the mice that reached adulthood had changed growth processes and a shortened life, and they were all barren.

However, the team thinks that these problems can be solved with some changes in the methods. Li states that this research is a fundamental scientific study and in this way the gene arrangement cannot be implemented in people, it provides important information about genetic obstacles to mammals in mammals.

Li emphasized once again that this research, including the protection of extinct species, has a very wide potential, “The two paternity mice in our study do not aim to be used as a model for human growth, but it provides important clues about mammal reproduction and genetic pressure,” he says.

The study was published in Cell Stem Cell magazine.